On a family of integrable systems on S2S^2 with a cubic integral of motion

We discuss a family of integrable systems on the sphere $S^2$ with an additional integral of third order in momenta. This family contains the Coryachev-Chaplygin top, the Goryachev system, the system recently discovered by Dullin and Matveev and two new integrable systems. On the non-physical sphere with zero radius all these systems are isomorphic to each other.Comment: LaTeX, 8 page

Radiation transfer in dispersion medium in separating

The influence of a degree of separating dispersion medium layer on radiation balance regarding its optical dimensions, scattering phase function shape and albedo of single scattering was investigated. It was stated that the bleaching effect occurring at dispersion medium separating has certain space boundaries. The classical concept of the «infinitely extended dispersion medium» was clarifie

Influence of space limited of the dispersion medium on image quality characteristics

Influence of space limited of the dispersion medium on radiation distribution and the quality characteristic of image obtained through dispersing medium of the finite sizes is investigated. The way of calculation of boundary function and contrast function of a light strip is determined. It is shown, that space limited of the dispersion medium and illumination conditions render significant influence on image quality -characteristics

Correction: Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes

Peer reviewedPublisher PD

Planning a Clinical Trial Programme for Medicinal Products for the Treatment of Axial Spondyloarthritis

The criteria for diagnosis and classification of spondyloarthritides (SpAs) have undergone significant changes over the past 10 years. The emergence of new diagnostic methods and availability of new information on the prognosis of the disease outcome made it possible to distinguish a separate group of SpAs—axial SpA. Axial SpA is distinguished as a separate disease due to its high social significance, and special mechanisms of its development. The development of medicinal products for the treatment of axial SpA has some specific features, which requires preparation of specific recommendations for conducting clinical trials of such products. The aim of the study was to elaborate a methodological approach to clinical research and evaluation of efficacy and safety of medicinal products for systemic treatment of axial SpA. The study took into account the requirements/recommendations of the European Medicines Agency for planning clinical trials of medicinal products for the treatment of axial SpA, in order to streamline evaluation of national and foreign clinical trial results. The paper identifies the main stages of clinical trials, and proposes criteria for assessing product efficacy at each stage. It defines methods and tools for assessing clinical trial endpoints, which are necessary for evaluation of treatment effects. The paper describes specific aspects of clinical trial designs and their duration, and identifies the objectives of exploratory and confirmatory clinical trials. It also reviews treatment goals and treatment outcome evaluation. The study results could be used in elaboration of recommendations for clinical research of new medicinal products for axial SpA

Searching for GUT-scale QCD Axions and Monopoles with a High Voltage Capacitor

The QCD axion has been postulated to exist because it solves the strong CP problem. Furthermore, if it exists axions should be created in the early Universe and could account for all the observed dark matter. In particular, axion masses of order $10^{-10}$ to $10^{-7}$ eV correspond to axions in the vicinity of the GUT-scale. In this mass range many experiments have been proposed to search for the axion through the standard QED coupling parameter $g_{a\gamma\gamma}$. Recently axion electrodynamics has been expanded to include two more coupling parameters, $g_{aEM}$ and $g_{aMM}$, which could arise if heavy magnetic monopoles exist. In this work we show that both $g_{aMM}$ and $g_{aEM}$ may be searched for using a high voltage capacitor. Since the experiment is not sensitive to $g_{a\gamma\gamma}$, it gives a new way to search for effects of heavy monopoles if the GUT-scale axion is shown to exist, or to simultaneously search for both the axion and the monopole at the same time